What Is Cuboid Syndrome?

Cuboid syndrome causes lateral, or side, midfoot pain. It is thought to be a result of injury to the calcaneocuboid joint because of a recurrent or forceful impact on the cuboid bone. The cuboid is a small midfoot bone that connects the outer metatarsals to the heel bone. A person with cuboid syndrome usually has swelling, lateral foot pain, and an unnatural gait. This can happen from running over a protrusion in the ground, such as a tree root, spraining one’s ankle that does not respond to treatment, or from peroneal tendinopathy, which is overuse of the peroneal tendons. Diagnosis is often made by taking a history of the patient, asking about any injuries incurred, and examining the foot. If you are suffering from lateral midfoot pain, it is a good idea to see a podiatrist for a proper diagnosis and treatment.

Cuboid syndrome, also known as cuboid subluxation, occurs when the joints and ligaments near the cuboid bone in the foot become torn. If you have cuboid syndrome, consult with Kenneth H. Nixon, DPM from Western Reserve Foot Clinic. Our doctor will assess your condition and provide you with quality foot and ankle treatment.

Cuboid syndrome is a common cause of lateral foot pain, which is pain on the outside of the foot. The condition may happen suddenly due to an ankle sprain, or it may develop slowly overtime from repetitive tension through the bone and surrounding structures.


The most common causes of cuboid syndrome include:

  • Injury – The most common cause of this ailment is an ankle sprain.
  • Repetitive Strain – Tension placed through the peroneus longus muscle from repetitive activities such as jumping and running may cause excessive traction on the bone causing it to sublux.
  • Altered Foot Biomechanics – Most people suffering from cuboid subluxation have flat feet.


A common symptom of cuboid syndrome is pain along the outside of the foot which can be felt in the ankle and toes. This pain may create walking difficulties and may cause those with the condition to walk with a limp.


Diagnosis of cuboid syndrome is often difficult, and it is often misdiagnosed. X-rays, MRIs and CT scans often fail to properly show the cuboid subluxation. Although there isn’t a specific test used to diagnose cuboid syndrome, your podiatrist will usually check if pain is felt while pressing firmly on the cuboid bone of your foot.


Just as the range of causes varies widely, so do treatments. Some more common treatments are ice therapy, rest, exercise, taping, and orthotics.

If you have any questions, please feel free to contact our office located in Stow, OH . We offer the newest diagnostic and treatment technologies for all your foot care needs.